Brieux, Jorge A.; Deulofeu, Venancio published an article in 1954, the title of the article was The reaction velocity of some substituted o- and p-chloro-nitrobenzenes with piperidine.Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene And the article contains the following content:
cf. C.A. 46, 2382i. The velocity constants for the reaction of some R-monosubstituted (R = Me, OMe, and OEt) o-and p-chloronitrobenzenes with piperidine (I) in C6H6 at 100° have been determined Possible reasons for the order of reactivity are given. Rates were measured at 100° by halide determination The rate constants were calculated for the over-all reaction O2NC6H3RCl + 2C5H10NH → O2NC6H3RNC5H10 + C5H10-NH.ClH. The mean deviation of the mean for the reaction of the rates was 2-3%. Average mean values of at least 2 independent runs expressed as 107k (1. mole-1sec.-1, are as follows for ClRC6H3NO2, where R = H, Me, MeO, and EtO, resp.: 4-ClC6H4NO2, 16.8, -, -, -; 4,3-ClRC6H3NO2, -, 0, 7.0, 4.16; 4,2-ClRC6H3NO2, -, 3.6, 14.1, 4.45; 2-ClC6H4NO2, 779, -, -, -; 2,3-ClRC6H3NO2, -, 5.55, 152, 123; 2,4-ClRC6H3NO2, -, 772, 2630, 1820; 2,5-Cl RC6H3NO2, -, 152, 35.9, 30.2; 2,6-ClRC6H3NO2, -, 12.1, 23.3, 9.73. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene
2-Chloro-4-methyl-1-nitrobenzene(cas:38939-88-7) belongs to chlorides. Alkanes and aryl alkanes may be chlorinated under free radical conditions, with UV light. However, the extent of chlorination is difficult to control. Aryl chlorides may be prepared by the Friedel-Crafts halogenation, using chlorine and a Lewis acid catalyst. Application In Synthesis of 2-Chloro-4-methyl-1-nitrobenzene
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics