On January 15, 2016, Cui, Zhishan; Li, Xi; Li, Lulu; Zhang, Bin; Gao, Chunmei; Chen, Yuzong; Tan, Chunyan; Liu, Hongxia; Xie, Weiyi; Yang, Ti; Jiang, Yuyang published an article.Related Products of 99-60-5 The title of the article was Design, synthesis and evaluation of acridine derivatives as multi-target Src and MEK kinase inhibitors for anti-tumor treatment. And the article contained the following:
Clin. studies have shown enhanced anticancer effects of combined inhibition of Src and MEK kinases. Development of multi-target drugs against Src and MEK is of potential therapeutic advantage against cancers. As a follow-up of our previous studies, and by using mol. docking method, we designed and synthesized a new series of 9-anilinoacridines containing phenyl-urea moieties as potential novel dual Src and MEK inhibitors. The anti-proliferative assays against K562 and HepG-2 tumor cells showed that most of the derivatives displayed good cytotoxicity in vitro. In particular, kinase inhibition assays showed that compound 8m inhibited Src (59.67%) and MEK (43.23%) at 10 μM, and displayed moderate inhibitory activity against ERK and AKT, the downstream effectors of both Src and MEK. Moreover, compound 8m was found to induce K562 cells apoptosis. Structure-activity relationships of these derivatives were analyzed. Our study suggested that acridine scaffold, particularly compound 8m, is of potential interest for developing novel multi-target Src and MEK kinase inhibitors. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Related Products of 99-60-5
The Article related to acridine derivative preparation src mek kinase inhibitor cancer, acridine, antitumor, apoptosis, kinase inhibitor, mek, src, Pharmacology: Structure-Activity and other aspects.Related Products of 99-60-5
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Chlorides – an overview | ScienceDirect Topics