Iwahashi, Maki; Naganawa, Atsushi; Kinoshita, Atsushi; Shimabukuro, Atsushi; Nishiyama, Toshihiko; Ogawa, Seiji; Matsunaga, Yoko; Tsukamoto, Kohki; Okada, Yutaka; Matsumoto, Ryoji; Nambu, Fumio; Oumi, Rie; Odagaki, Yoshihiko; Katagi, Jun; Yano, Koji; Tani, Kousuke; Nakai, Hisao; Toda, Masaaki published an article in 2011, the title of the article was Discovery of new orally active prostaglandin D2 receptor antagonists.Recommanded Product: 59833-69-1 And the article contains the following content:
To identify an orally available drug candidate, a series of 3-benzoylaminophenylacetic acids were synthesized and evaluated as prostaglandin D2 (PGD2) receptor antagonists. Some of the compounds tested were found to exhibit excellent inhibitory activity against cAMP accumulation in human platelet rich plasma (hPRP), which is one of the indexes of DP antagonism. The optimization process including improvement of the physicochem. properties such as solubility, which may result in an improved pharmacokinetic (PK) profile, is presented. Optimized compounds were studied for their pharmacokinetics and in vivo potential. A structure-activity relation study is also presented. Some of the test compounds were found to have in vivo efficacy towards the inhibition of PGD2-induced and OVA-induced vascular permeability in guinea pig conjunctiva. The experimental process involved the reaction of Methyl 2-(3-amino-4-chlorophenyl)acetate(cas: 59833-69-1).Recommanded Product: 59833-69-1
The Article related to prostaglandin d2 receptor antagonist preparation and structure activity, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 59833-69-1
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics