Kaur, Avneet; Pathak, Dharam P.; Sharma, Vidushi; Wakode, Sharad published an article in 2018, the title of the article was Synthesis, molecular docking, and pharmacological evaluation of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives as selective COX-2 inhibitors and anti-inflammatory agents.Recommanded Product: 2-Chloro-4-nitrobenzoic acid And the article contains the following content:
A series of N-(2-(3,5-dimethoxyphenyl)benzoxazole-5-yl)benzamide derivatives was synthesized and evaluated for their in vitro inhibitory activity against COX-1 and COX-2. The compounds with considerable in vitro activity (IC50 < 1 μM) were evaluated in vivo for their anti-inflammatory potential by the carrageenan-induced rat paw edema method. Out of 13 newly synthesized compounds, six compounds were found to be the most potent COX-2 inhibitors in the in vitro enzymic assay, with IC50 values in the range of 0.06-0.71 μM. The in vivo anti-inflammatory activity of these compounds was assessed by the carrageenan-induced rat paw edema method. Compounds I (84.09%), II (79.54%), and III (70.45%) demonstrated significant anti-inflammatory activity compared to the standard drug ibuprofen (65.90%) and were also found to be safer than ibuprofen, by ulcerogenic studies. A docking study was done using the crystal structure of human COX-2, to understand the binding mechanism of these inhibitors to the active site of COX-2. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Recommanded Product: 2-Chloro-4-nitrobenzoic acid
The Article related to docking cox2 inhibitor antiinflammatory inflammation, cox-1, cox-2, n-(3,5-dimethoxphenyl)-benzoxazole, anti-inflammatory activity, ulcerogenic activity, Pharmacology: Structure-Activity and other aspects.Recommanded Product: 2-Chloro-4-nitrobenzoic acid
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics