On October 31, 1983, Naganuma, Masayuki; Ohtsu, Yutaka; Katsumura, Yoshio; Matsuoka, Masahiro; Morikawa, Yoshihiro; Tanaka, Muneo; Mitsui, Takeo published an article.Category: chlorides-buliding-blocks The title of the article was Analysis of subsidiary colors in Red Number 204 and its purification. Development of non-allergenic Red Number 204. And the article contained the following:
Red Number 204 (Lake Red CBA) [5160-02-1], used for make-up products including lipstick, was analyzed for its organic impurities. These impurities were isolated by high-performance liquid chromatog. and their structural formulas were confirmed by various anal. methods. Many kinds of aromatic azo compounds (subsidiary colors) were found. The subsidiary colors were 11 kinds including Sudan 1. These subsidiary colors and the related compounds were synthesized for use as the standard samples. The subsidiary colors in Lake Red CBA showed pos. results with the modified guinea pig maximization test indicating that each of them was a contact sensitizer, while Lake Red CBA itself was not. Lake Red CBA synthesized with C acid [88-53-9] from which aromatic amines were removed contained no subsidiary color. When Lake Red CBA was synthesized with the purified C acid to which 3 types of the typical aromatic amines were added in fixed quantity, the corresponding aromatic azo compounds were produced in proportion to the added amounts of aromatic amines. The preparation of Sudan III, Orange II, Quinoline Yellow WS, Quinizarin Green SS, etc., free from contact sensitive impurities, for use in cosmetic products is discussed. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Category: chlorides-buliding-blocks
The Article related to allergy red 204 cosmetic, sensitizer lake red cba, Essential Oils and Cosmetics: General and other aspects.Category: chlorides-buliding-blocks
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics