On November 5, 2018, Nechipadappu, Sunil Kumar; Trivedi, Darshak R. published an article.COA of Formula: C7H4ClNO4 The title of the article was Cocrystal of nutraceutical sinapic acid with Active Pharmaceutical Ingredients ethenzamide and 2-chloro-4-Nitrobenzoic acid: Equilibrium solubility and stability study. And the article contained the following:
Sinapic acid (SNP) is a nutraceutical compound of hydroxybenzoic acid derivative which possesses anti-oxidant, anti-microbial, anti-inflammatory, anti-cancer, and anti-anxiety activity properties. In the present work, two cocrystals of SNP with two active drug ingredients such as Ethenzamide (ETZ) and 2-chloro-4-nitrobenzoic acid (CNB) are reported. Both the cocrystals were synthesized via simple solvent evaporation method and the crystal structures were characterized by Single Crystal X-ray Diffraction (SC-XRD) techniques. The cocrystals were formed via robust acid-amide heterosynthon and acid-acid homosynthon between SNP and drug mols. Both the cocrystals were crystallized in monoclinic crystal system with P 21/c space group. The synthesized cocrystals were further characterized by DSC, PXRD, FT-IR, and 1H NMR techniques. The solubility study in purified distilled water and in 0.1 N HCl solution demonstrate that there was no increment in the solubility of drug mols. in the cocrystals in both purified water and in 0.1 N HCl solution The synthesized cocrystal exhibited six months stability at ambient conditions (∼25 °C, 60-65% RH). The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).COA of Formula: C7H4ClNO4
The Article related to cocrystal nutraceutical sinapic acid ethenzamide nitrobenzoic acid solubility stability, Pharmaceuticals: Pharmaceutics and other aspects.COA of Formula: C7H4ClNO4
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics