On July 1, 2010, Peace, Simon; Philp, Joanne; Brooks, Carl; Piercy, Val; Moores, Kitty; Smethurst, Chris; Watson, Steve; Gaines, Simon; Zippoli, Mara; Mookherjee, Claudette; Ife, Robert published an article.Formula: C7H6ClNO2 The title of the article was Identification of a sulfonamide series of CCR2 antagonists. And the article contained the following:
A series of sulfonamide CCR2 antagonists was identified by high-throughput screening. Management of mol. weight and phys. properties, in particular moderation of lipophilicity and study of pKa, yielded highly potent CCR2 antagonists exhibiting good pharmacokinetic properties and improved potency in the presence of human plasma. The experimental process involved the reaction of 2-Chloro-4-methyl-1-nitrobenzene(cas: 38939-88-7).Formula: C7H6ClNO2
The Article related to ccr2 antagonist sulfonamide preparation sar, Pharmacology: Structure-Activity and other aspects.Formula: C7H6ClNO2
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics