On October 1, 2015, Song, Kebiao; Xu, Xing; Liu, Peng; Chen, Lili; Shen, Xu; Liu, Junhua; Hu, Lihong published an article.Related Products of 99-60-5 The title of the article was Discovery and SAR study of 3-(tert-butyl)-4-hydroxyphenyl benzoate and benzamide derivatives as novel farnesoid X receptor (FXR) antagonists. And the article contained the following:
3-(Tert-Butyl)-4-hydroxyphenyl 2,4-dichlorobenzoate (1) was discovered in our inhouse high throughput screening as a moderate FXR antagonist. To improve the potency and the stability of the hit 1, forty derivatives were synthesized and SAR was systematically explored. The results turn out that replacing the 2,4-dichlorophenyl with 2,6-dichloro-4-amidophenyl shows great improvement in potency, replacing the benzoate with benzamide shows improvement in stability and slight declining of potency and 3-(tert-butyl)-4-hydroxyphenyl unit is essential in obtaining the FXR antagonistic activity. The experimental process involved the reaction of 2-Chloro-4-nitrobenzoic acid(cas: 99-60-5).Related Products of 99-60-5
The Article related to farnesoid fxr antagonist benzoate benzamide derivative preparation structure activity, fxr, fxr antagonist, non-steroidal, sar study, Pharmacology: Structure-Activity and other aspects.Related Products of 99-60-5
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics