On February 28, 2011, Yamaoka, Nagahisa; Kodama, Hidehiko; Izuhara, Yuko; Miyata, Toshio; Meguro, Kanji published an article.COA of Formula: C7H11ClO3 The title of the article was Structure-activity relationships of new N-acylanthranilic acid derivatives as plasminogen activator inhibitor-1 inhibitors. And the article contained the following:
Novel anthranilic acid derivatives having substituted N-acyl side chains were designed and synthesized for evaluation as plasminogen activator inhibitor-1 (PAI-1) inhibitors. Compounds with a 4-diphenylmethyl-1-piperazinyl moiety on the acyl side chains in general exhibited potent in vitro PAI-1 inhibitory activity and good pharmacokinetic profiles after oral administration in rats. Compound TM5275 was identified as a promising candidate for further pharmacol. evaluation. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).COA of Formula: C7H11ClO3
The Article related to acylanthranilate derivative preparation pai 1 inhibitor structure activity pharmacokinetics, Pharmacology: Structure-Activity and other aspects.COA of Formula: C7H11ClO3
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics