On November 1, 2014, Yang, Wei; Li, Lixuan; Ji, Xun; Wu, Xiaowei; Su, Mingbo; Sheng, Li; Zang, Yi; Li, Jia; Liu, Hong published an article.Formula: C7H11ClO3 The title of the article was Design, synthesis and biological evaluation of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel histone deacetylase inhibitors. And the article contained the following:
A series of 4-anilinothieno[2,3-d]pyrimidine-based hydroxamic acid derivatives as novel HDACs inhibitors were designed, synthesized and evaluated. Most of these compounds displayed good to excellent inhibitory activities against HDAC1, 3, 6. The IC50 values of compound 10r against HDAC1, HDAC3, HDAC6 was 1.14 ± 0.03 nM, 3.56 ± 0.08 nM, 11.43 ± 0.12 nM. Compound 10r noticeably up-regulated the level of histone H3 acetylation compared to the SAHA. Most of the compounds showed the strong anti-proliferative activity against human cancer cell lines including RMPI8226 and HCT-116. The IC50 values of Compounds 10r and 10t against RPMI8226 was 2.39 ± 0.20 μM, 1.41 ± 0.44 μM, resp., and the HCT-116 was sensitive to the compounds 10h, 10m, 10r, 10w with the IC50 values <1.9 μM. The experimental process involved the reaction of Methyl 6-chloro-6-oxohexanoate(cas: 35444-44-1).Formula: C7H11ClO3
The Article related to anilinothieno pyrimidine hydroxamate derivative preparation histone deacetylase inhibitor cancer, hdacs, hdacs inhibitor, hydroxamic acid, thieno[2,3-d]pyrimidines, Pharmacology: Structure-Activity and other aspects.Formula: C7H11ClO3
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics