Andres, Miriam published the artcile2-(1H-Pyrazol-1-yl)acetic acids as chemoattractant receptor-homologous molecule expressed on Th2 lymphocytes (CRTh2) antagonists, Application of Ethyl 2,5-dichlorobenzoate, the main research area is pyrazolylacetate preparation chemoattractant receptor antagonist; CRTh2 antagonists; Pyrazole; Structure–activity relationship (SAR).
In this manuscript, the synthesis and biol. activity of a series of pyrazole acetic acids, e.g. I [R1 = H, 4-MeO, 5-F, etc.; R2 = Ph, 2-FC6H4, 3-ClC6H4; X= SO2, S] as CRTh2 antagonists is presented. Biol. evaluation in vitro revealed that the pyrazole core showed in several cases a different structure-activity relationship to that of related indole acetic acid. A potent series of ortho-sulfonyl benzyl substituents was found, from which two compounds I [R1 = H; R2 = Ph; X = SO2] and I [R1 = H; R2 = 4-FC6H4; X = SO2] were advanced to in vivo profiling.
European Journal of Medicinal Chemistry published new progress about Structure-activity relationship, receptor-binding. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Application of Ethyl 2,5-dichlorobenzoate.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics