Hilfiker, Mark A.’s team published research in Bioorganic & Medicinal Chemistry Letters in 2009-08-01 | CAS: 89978-31-4

Bioorganic & Medicinal Chemistry Letters published new progress about Drug bioavailability. 89978-31-4 belongs to class chlorides-buliding-blocks, name is 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, and the molecular formula is C8H5Cl2N3S, Application In Synthesis of 89978-31-4.

Hilfiker, Mark A. published the artcileDiscovery of novel aminothiadiazole amides as selective EP3 receptor antagonists, Application In Synthesis of 89978-31-4, the main research area is aminothiadiazole amide preparation antagonist EP3 receptor.

This Letter discloses a series of 2-aminothiadiazole amides as selective EP3 receptor antagonists. Structure-activity relationship (SAR) optimization resulted in compounds with excellent functional activity in vitro. In addition, efforts to optimize DMPK properties in the rat are discussed. These efforts have resulted in the identification of potent, selective EP3 receptor antagonists with excellent DMPK properties suitable for in vivo studies.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug bioavailability. 89978-31-4 belongs to class chlorides-buliding-blocks, name is 5-(2,6-Dichlorophenyl)-1,3,4-thiadiazol-2-amine, and the molecular formula is C8H5Cl2N3S, Application In Synthesis of 89978-31-4.

Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics