Keith, John M. published the artcileHeteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase, Computed Properties of 61343-99-5, the main research area is heteroaryl urea fused bicyclic diamine core preparation; fatty acid amide hydrolase inhibitory activity; Anandamide; Aryl urea; Covalent inhibitor; Endocannabinoid; Enzyme; FAAH; Inhibitors; Serine hydrolase.
A series of mechanism-based heteroaryl urea fatty acid amide hydrolase (FAAH) inhibitors with fused bicyclic diamine cores is described. In contrast to compounds built around a piperazine core, most of the fused bicyclic diamine bearing analogs prepared exhibited greater potency against rFAAH than the human enzyme. Several compounds I and II equipotent against both species were identified and profiled in vivo.
Bioorganic & Medicinal Chemistry Letters published new progress about Enzyme inhibitors (fatty acid amide hydrolase). 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Computed Properties of 61343-99-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics