Kim, Ikyon published the artcileDesign, synthesis, and evaluation of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines as novel PDE-4 inhibitors, Recommanded Product: Ethyl 2,5-dichlorobenzoate, the main research area is aryldialkoxyphenylpyrazolopyrimidine preparation PDE4 inhibitor.
Described herein is design, synthesis, and biol. evaluation of novel series of 2-aryl-7-(3′,4′-dialkoxyphenyl)-pyrazolo[1,5-a]pyrimidines acting as inhibitors of type 4 phosphodiesterase (PDE4) which is known as a good target for the treatment of asthma and COPD. For this purpose, structure optimization was conducted with the aid of structure-based drug design using the known X-ray crystallog. Also, biol. effects of these compounds on the target enzyme were evaluated by using in vitro assays, leading to the potent and selective PDE-4 inhibitor (IC50 < 10 nM). Bioorganic & Medicinal Chemistry Letters published new progress about Asthma. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Recommanded Product: Ethyl 2,5-dichlorobenzoate.
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