Mikami, Shinichi published the artcileSilica gel-assisted preparation of 2,4,7-trihalobenzo[b]thiophenes and 4,7-dihalobenzo[b]thiophenes, Recommanded Product: 3-Bromo-6-chloro-2-fluorobenzaldehyde, the main research area is halobenzothiophene preparation.
All 6 isomers of (bromo)(chloro)(iodo)benzo[b]thiophenes containing three different halogen atoms at the 2-, 4- and 7-positions I (X = I, Br, Cl; Y = I, Br, Cl; Z = I, Br, Cl) were synthesized from the corresponding 2-(1-adamantylsulfanyl)-1,4-dihalo-3-(haloethynyl)benzene derivatives 2-RS-3-ZCC-4-XC6H2Y (R = adamantan-1-yl), through treatment with silica gel under thermal conditions. In contrast to the previous method using gold chloride catalyst, migration of adamantyl group did not occur in this method using silica gel. Moreover, by using this method, 6 types of 4,7-dihalobenzo[b]thiophenes I (Z = H) have been synthesized in 4 steps from 2-fluoro-3,6-dihalo-benzaldehydes 2-F-3Y-6-XC6H2CHO in moderate to excellent overall yields (42-82%).
Phosphorus, Sulfur and Silicon and the Related Elements published new progress about Aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 886615-30-1 belongs to class chlorides-buliding-blocks, name is 3-Bromo-6-chloro-2-fluorobenzaldehyde, and the molecular formula is C7H3BrClFO, Recommanded Product: 3-Bromo-6-chloro-2-fluorobenzaldehyde.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics