Senkardes, Sevil published the artcileSynthesis, antimicrobial properties and in silico studies of aryloxyacetic acid derivatives with hydrazone or thiazolidine-4-one scaffold, Application In Synthesis of 93118-03-7, the main research area is arylideneamino phenoxyacetamide preparation antibacterial antifungal SAR docking; arylthiazolidinyl phenoxyacetamide preparation antibacterial antifungal SAR docking; 4-thiazolidinone; Cresol; antimicrobial activity; hydrazone; molecular docking.
In this work, twenty hydrazide-hydrazones I [Ar = 3,5-dimethylphenyl, 2-chloro-3-methoxyphenyl, 4-phenylthiophen-2-yl, etc.] and 4-thiazolidinone derivatives II were synthesized starting from m-cresol. Antimicrobial evaluation was carried out by microdilution method against Enterococcus faecalis and Staphylococcus aureus as Gram-pos. bacteria and Escherichia coli and Pseudomonas aeruginosa as Gram-neg. bacteria, and three pathogenic fungi Candida albicans, Candida parapsilosis and Candida krusei. Some compounds possessed considerable antimicrobial properties against the tested microorganisms, particularly against E. coli. Compounds II [Ar = 3-methoxyphenyl, 3,5-dichlorophenyl] were found to be the most active derivatives with MICs of 2 μg/mL against E. coli and compounds I [Ar = 3,5-dichlorophenyl] also displayed antifungal activity against Candida krusei that was comparable to fluconazole. Calculated drug-likeness and ADMET parameters of the most active compounds confirmed their potential as antimicrobial drug candidates. Mol. docking investigations were carried out in the thiamine diphosphate-binding site of pyruvate dehydrogenase multienzyme complex E1 component (PDHc-E1) to clarify the potential antibacterial mechanism against E. coli. The results showed the potential and importance of developing new hydrazones and 4-thiazolidinones that would be effective against microbial strains.
Journal of Biomolecular Structure and Dynamics published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application In Synthesis of 93118-03-7.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics