Huang, Hai-Yun published the artcilePd-Catalyzed Direct Arylations of Heteroarenes with Polyfluoroalkoxy-Substituted Bromobenzenes, COA of Formula: C7H3BrClF3O, the main research area is fluoroalkoxy bromobenzene heteroarene palladium catalyst arylation; arylated heteroarene preparation.
The reactivity of di-, tri- and tetra-fluoroalkoxy-substituted bromobenzenes in the direct arylation of 5-membered ring heteroarenes using palladium catalysis was explored. High yields in arylated heteroarenes, e.g., I, were obtained using only 1 mol-% of Pd(OAc)2 catalyst with KOAc as an inexpensive base. Similar yields were obtained with o/m/p trifluoromethoxy-, o/p difluoromethoxy-, and tetrafluoroethoxy-substituents on the aryl bromide. A bromo-substituted difluorobenzo[d][1,3]dioxole was successfully coupled. The major side-products of the reaction are HBr/KOAc. Therefore, this synthetic scheme is very attractive for the access to such polyfluoroalkoxy-containing arylated heteroaromatics in terms of cost, simplicity, and low environmental impact, compared to reactions involving arylation of heteroarenes with bromophenols followed by polyfluoroalkylation.
European Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent) (fluoroalkoxy). 468075-00-5 belongs to class chlorides-buliding-blocks, name is 2-Bromo-1-chloro-4-(trifluoromethoxy)benzene, and the molecular formula is C7H3BrClF3O, COA of Formula: C7H3BrClF3O.
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