Dey, Aniruddha published the artcileNickel-catalyzed deamidative step-down reduction of amides to aromatic hydrocarbons, Quality Control of 36428-96-3, the main research area is reduction diamidation aromatic amide hydrocarbon preparation nickel catalyst; aryl pyrazolyl azaindolyl ketone amide reduction tetramethyldisiloxane nickel catalyst; crystal structure ethyldiphenylphosphine dicarbonyl pyrazolyl naphthalenecarboxylate nickel complex; mol structure ethyldiphenylphosphine dicarbonyl pyrazolyl naphthalenecarboxylate nickel complex.
To date, cleavage of the C-N bond in aromatic amides has been achieved in mols. with a distorted constitutional framework around the nitrogen atom. In this report, a nickel-catalyzed reduction of planar aromatic amides to the corresponding lower aromatic hydrocarbon homolog has been reported. Tetramethyldisiloxane reduction of aromatic amides ArCOPz, ArCOAInd (Pz = 1-pyrazolyl, AInd = 7-aza-1-indolyl), catalyzed by Ni(cod)2/EtPPh2 gave the corresponding hydrocarbons ArH (Ar = 1-naphthyl, 2-naphthyl, 9-anthracenyl, 2-pyrenyl) with high yields. This involves a one-pot reductive cleavage of the C-N bond followed by a tandem C-CO bond break in the presence of a hydride source. Substrate scope circumscribes deamidation examples which proceed via oxidative addition of nickel in the amide bonds of nontwisted amides. Mechanistic studies involving isolation and characterization of involved intermediates via different spectroscopic techniques reveal a deeper introspection into the plausible catalytic cycle for the methodol.
ACS Catalysis published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent). 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Quality Control of 36428-96-3.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics