Gottumukkala, Aditya L. published the artcileEfficient Formation of Benzylic Quaternary Centers via Palladium Catalysis, Synthetic Route of 480438-56-0, the main research area is palladium catalyst conjugate addition arylboronic acid enone; CC coupling reactions; arylations; enones; ligands; palladium.
Pd(O2CCF3)2 and 2,2-bipyridine catalyzed the formation of benzylic quaternary centers from arylboronic acids and β-disubstituted enones. For cyclic substrates, only 1 mol% of palladium is required for full conversion, and a variety of arylboronic acids could be reacted with yields exceeding 90%. 5-Membered cyclic enones were found to be most reactive, followed by 6-membered rings and then 7-membered rings. E.g., reaction of 3-methyl-2-cyclohexenone and PhB(OH)2 gave 92% I. In the case of acyclic substrates, e.g. (E)-Me3COCH2CMe:CHCOMe, 5 mol% Pd was found to be necessary, along with the addition of 20 mol% KSbF6 to afford the highest conversion.
ChemSusChem published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 480438-56-0 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-isopropoxyphenylboronic acid, and the molecular formula is C9H12BClO3, Synthetic Route of 480438-56-0.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics