Liu, Zhenghui published the artcileSmall organic molecules with tailored structures: initiators in the transition-metal-free C-H arylation of unactivated arenes, Formula: C6H3ClFI, the main research area is biaryl preparation; unactivated arene aryl iodide arylation methylaminophenyl methanol catalyst.
In this article, an optimized catalytically active mol., (2-(methylamino)phenyl)methanol, was designed. A broad range of aryl iodides RI (R = 2-fluorophenyl, thiophen-3-yl, pyridin-4-yl, etc.) could be converted into the corresponding arylated products RR1 (R1 = Ph, 4-methylphenyl) at 100°C over 24 h with good to excellent yields. Mechanistic experiments verified that radicals participated in this catalytic transformation and that the cleavage of the aromatic C-H bond was not the rate determining step. A K+ capture experiment by 18-crown-6 emphasized the significance of the cation species of the strong base. Fourier transform IR spectroscopy proved that the catalytic system was activated by the hydrogen bonds between small organic mols. and tBuOK. Also, a clear mechanism was proposed. This transition-metal-free method affords a promising system for efficient and inexpensive synthesis of biaryls via a user-friendly approach, as confirmed by scale-up experiments
RSC Advances published new progress about Aryl iodides Role: RCT (Reactant), RACT (Reactant or Reagent). 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, Formula: C6H3ClFI.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics