Parle, Amrita published the artcileSynthesis, characterization and evaluation of 3-acetylindole derivatives as potential antifungal agents, Application In Synthesis of 93118-03-7, the main research area is acetylindole preparation antifungal activity.
In the present study, a series of novel 3-acetylindole derivatives I (R = 3,5-dibromophenyl, 2-chloro-5-nitrophenyl, 2-(trifluoromethoxy)phenyl, etc.) was synthesized by reacting 3-acetylindole and benzaldehydes RCHO. The synthesized 3-acetylindole derivatives I were characterized physicochem., by elemental anal. and spectral (IR and 1H-NMR) anal. The synthesized compounds I were screened for their in-vitro antifungal activity against Candida albicans, Rhizopus oligosporus, Gibberella fuzikuroi and Asperigillus niger by cup plate method. The results revealed that five compounds namely I (R = 5-hydroxy-2-nitrophenyl, 2-chloro-3-(trifluoromethyl)phenyl, 4-nitrophenyl, 4-methoxy-3-nitrophenyl and 5-chloro-2-nitrophenyl) have better or equal antifungal activity compared to the standard fluconazole.
Pharma Innovation published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application In Synthesis of 93118-03-7.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics