Bester, Stephanie M. published the artcileStructural and mechanistic bases for a potent HIV-1 capsid inhibitor, Application of 3-Bromo-6-chloro-2-fluorobenzaldehyde, the main research area is GS 6207 preparation antiviral HIV1 capsid inhibitor.
The potent HIV-1 capsid inhibitor GS-6207 is an investigational principal component of long-acting antiretroviral therapy. We found that GS-6207 inhibits HIV-1 by stabilizing and thereby preventing functional disassembly of the capsid shell in infected cells. X-ray crystallog., cryo-electron microscopy, and hydrogen-deuterium exchange experiments revealed that GS-6207 tightly binds two adjoining capsid subunits and promotes distal intra- and inter-hexamer interactions that stabilize the curved capsid lattice. In addition, GS-6207 interferes with capsid binding to the cellular HIV-1 cofactors Nup153 and CPSF6 that mediate viral nuclear import and direct integration into gene-rich regions of chromatin. These findings elucidate structural insights into the multimodal, potent antiviral activity of GS-6207 and provide a means for rationally developing second-generation therapies.
Science (Washington, DC, United States) published new progress about Anti-HIV agents (anti-HIV-1 agents). 886615-30-1 belongs to class chlorides-buliding-blocks, name is 3-Bromo-6-chloro-2-fluorobenzaldehyde, and the molecular formula is C7H3BrClFO, Application of 3-Bromo-6-chloro-2-fluorobenzaldehyde.
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Chlorides – an overview | ScienceDirect Topics