Fuller, Ray W. published the artcileNorepinephrine N-methyltransferase inhibition by benzamidines, phenylacetamidines, benzylguanidines, and phenylethylguanidines, HPLC of Formula: 50292-25-6, the main research area is norepinephrine methyltransferase inhibitor amidine; guanidine aryl methyltransferase inhibitor.
Mono- and dichloro derivatives of 21 title compounds and 18 benzylamines, α-methylbenzylamines, and amphetamines were studied as inhibitors of norepinephrine N-methyltransferase (EC 2.1.1.28) [9037-68-7]. The 2 most effective inhibitors in vitro were 2,3-dichlorobenzamidine-HCl (I-HCl) [55154-87-5] and 3,4-dichlorophenylacetamidine (II) [55154-91-1] with pI50 values of 5.55 and 5.36, resp. I and II are reversible inhibitors and competitive with norepinephrine in vitro, but are not effective in blocking enzyme activity in vivo in rats.
Journal of Medicinal Chemistry published new progress about Structure-activity relationship. 50292-25-6 belongs to class chlorides-buliding-blocks, name is 3,4-Dichlorobenzene-1-carboximidamide hydrochloride, and the molecular formula is C7H7Cl3N2, HPLC of Formula: 50292-25-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics