Lemrova, Barbora published the artcileSolid-Phase Synthesis of 4,7,8-Trisubstituted 1,2,3,4-Tetrahydro-benzo[e][1,4]diazepin-5-ones, Application In Synthesis of 35112-05-1, the main research area is benzodiazepinone solid phase preparation chlorofluoronitrobenzoic acid synthon; benzodiazocinone thiazine thiazepine derivative solid phase preparation.
Solid-phase synthesis of 1,2,3,4-tetrahydro-benzo[e][1,4]diazepin-5-ones with the use of a polystyrene resin is described. The starting material was polymer-supported 1,2-diaminoethane and 4-chloro-2-fluoro-5-nitrobenzoic acid was used as a key synthon. The synthetic approach allows the preparation of derivatives with variable substitution at positions 4 and 8. Addnl., a skeletal diversity was increased when the nitro group was reduced and some benzene fused heterocycles were prepared An expansion of a diazepinone to a benzodiazocinone scaffold was also successful, although some limitations in the diversity of the target derivatives were observed
ACS Combinatorial Science published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 35112-05-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoro-5-nitrobenzoic acid, and the molecular formula is C7H3ClFNO4, Application In Synthesis of 35112-05-1.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics