Uhm, Ki-Nam published the artcileEnantioselective resolution of methyl 2-chloromandelate by Candida antarctica lipase A in a solvent-free transesterification reaction, Name: (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, the main research area is lipase resolution chloromandelate ester.
Enantiomerically pure 2-chloromandelic acid esters are important chiral building blocks for synthesis of a wide range of pharmaceutical products, such as an anti-thrombotic agent, (S)-clopidogrel. An efficient and novel process for resolution of Me 2-chloromandelate was developed by using a lipase-mediated transesterification. Among 11 hydrolytic enzymes examined, Candida antarctica lipase A (CAL-A) showed the highest enantioselectivity and reaction rate toward Me (S)-2-chloromandelate. Me (R)-2-chloromandelate was obtained in enantiomerically pure form (>99% ee) and 41% yield through the lipase-mediated resolution under a solvent-free condition. CAL-A maintained its catalytic activity during 13 cycles of repeated use without significant decrease in enantioselectivity, indicating that the method is economical and easy to scale-up for com. production of Me (R)-2-chloromandelate.
Journal of Molecular Catalysis B: Enzymatic published new progress about Acylation, stereoselective (enzymic). 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Name: (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate.
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