Wales, Steven M. published the artcileBenzoazepine-Fused Isoindolines via Intramolecular (3 + 2)-Cycloadditions of Azomethine Ylides with Dinitroarenes, HPLC of Formula: 1214344-25-8, the main research area is benzazepine fused isoindoline diastereoselective preparation; nitrobenzylaminobenzaldehyde glycine cycloaddition.
Aminobenzaldehydes bearing a pendant 3,5-dinitrophenyl group react thermally with N-substituted α-amino acids to form unprecedented benzazepine-fused isoindolines, e.g., I. The reaction proceeds via a dearomatization/rearomatization sequence involving an intramol. [3 + 2]-cycloaddition between the in situ formed azomethine ylide and the dinitroarene. Various glycine derivatives are tolerated as well as branched substrates based on cyclic, α-mono-, and α,α-disubstituted amino acids, giving single diastereomers in many cases. The method is scalable and gives products with a nitro group ready for further manipulation.
Organic Letters published new progress about [3+2] Cycloaddition reaction (intramol.). 1214344-25-8 belongs to class chlorides-buliding-blocks, name is 1-(Chloromethyl)-3-fluoro-5-nitrobenzene, and the molecular formula is C7H5ClFNO2, HPLC of Formula: 1214344-25-8.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics