Wang, Huan published the artcileCationic palladium(II)-catalyzed synthesis of 2-substituted 3-hydroxymethylbenzo[b]furans, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is hydroxymethylbenzofuran preparation; benzofuran hydroxymethyl preparation; alkynyl phenol preparation heterocyclization aldehyde palladium catalyst.
A tandem reaction involving an intramol. oxypalladation of an alkyne and an addition to the carbonyl group to quench the carbon-palladium bond to complete the catalytic cycle was developed. The reaction of 2-alkynylphenols with aldehydes to prepare substituted 3-(hydroxymethyl)benzofurans in one pot is described. E.g, reaction of 2-(phenylethynyl)phenol and p-nitrobenzaldehyde, catalyzed by [Pd(dppp)(H2O)2](BF4)2, gave 90% benzofuran (I). The reaction was catalyzed with the cationic palladium(II) species without the necessity of a redox system.
Synlett published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics