Hossain, Mohammad Anwar published the artcileDesign, synthesis, and evaluation of compounds capable of reducing Pseudomonas aeruginosa virulence, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde, the main research area is Pseudomonas aeruginosa virulence synthesis compound; Anti-virulence; Ciprofloxacin; P. aeruginosa; Quorum sensing.
Anti-virulence approaches in the treatment of Pseudomonas aeruginosa (PA)-induced infections have shown clin. potential in multiple in vitro and in vivo studies. However, development of these compounds is limited by several factors, including the lack of mols. capable of penetrating the membrane of gram-neg. organisms. Here, we report the identification of novel structurally diverse compounds that inhibit PqsR and LasR-based signaling and diminish virulence factor production and biofilm growth in two clin. relevant strains of P. aeruginosa. It is the first report where potential anti-virulent agents were evaluated for inhibition of several virulence factors of PA. Finally, co-treatment with these inhibitors significantly reduced the production of virulence factors induced by the presence of sub-inhibitory levels of ciprofloxacin. Further, we have analyzed the drug-likeness profile of designed compounds using quant. estimates of drug-likeness (QED) and confirmed their potential as hit mols. for further development.
European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Recommanded Product: 4-(4-Chlorophenoxy)benzaldehyde.
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