Kersten, Philip published the artcileEnzymic release of halogens or methanol from some substituted protocatechuic acids, Synthetic Route of 62936-23-6, the main research area is protocatechuate metabolism bacteria halogen methanol.
Four strains of gram-neg. bacteria capable of growing at the expense of 5-chlorovanillate were isolated from soil, and the metabolism of 1 strain was studied in particular detail. In the presence of α,α’-bipyridyl, a suspension of 5-chlorovanillate-grown cells accumulated 5-chloroprotocatechuate from 5-chlorovanillate; in the absence of inhibitor these compounds, and various other 5-substituted protocatechuates and vanillates, were oxidized to completion. Cell suspensions of this strain grown on 5-chlorovanillate or vanillate released Cl- quant. from 5-chlorovanillate and released MeOH from syringate. Extracts of cells grown with 4-hydroxybenzoate, vanillate, or syringate possessed high levels of both protocatechuate 4,5-dioxygenase and 2-pyrone-4,6-dicarboxylate hydrolase; extracts from acetate-grown cells did not. Protocatechuate 4,5-dioxygenase, purified from strains that could grow with 5-chlorovanillate, oxidized 5-halogeno-protocatechuates and 3-O-methylgallate with the formation of 2-pyrone-4,6-dicarboxylate. A crude extract converted 5-chloroprotocatechuate into pyruvate plus oxaloacetate. A meta-fission reaction sequence is proposed for the bacterial degradation of vanillate and protocatechuate substituted at C-5 of the benzene ring with halogen or methoxyl.
Journal of Bacteriology published new progress about Comamonas testosteroni. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Synthetic Route of 62936-23-6.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics