Li, Yan published the artcileStereoselective synthesis and fungicidal activities of (E)-α-(methoxyimino)-benzeneacetate derivatives containing 1,3,4-oxadiazole ring, Application In Synthesis of 35112-27-7, the main research area is stereoselective synthesis fungicidal activity methoxyiminobenzeneacetate oxadiazolyl.
Fifteen novel (E)-α-(methoxyimino)benzeneacetate derivatives, the analogs of strobilurins, which contain two pharmacophoric substructures of (E)-Me methoxyiminoacetate moiety and 1,3,4-oxadiazole ring were stereoselectively synthesized. It was first found that the coupling reaction could give stereoselectively the key intermediate (E)- and (Z)-Me 2-(hydroxyimino)-2-o-tolylacetate with a ratio of 14:1. The preliminary bioassays indicated that all the compounds I (R = H, 4-MeO, 2,3-Cl2, 2-I, etc.) showed potent fungicidal activity against Rhizoctonia solani, Botrytis cinereapers, Gibberella zeae, Physalospora piricola and Bipolaris mayclis, and all of the tested compounds had more potent fungicidal activities against R. solani than Kresoxim-Me.
Bioorganic & Medicinal Chemistry Letters published new progress about Agrochemical fungicides. 35112-27-7 belongs to class chlorides-buliding-blocks, name is Ethyl 2,5-dichlorobenzoate, and the molecular formula is C9H8Cl2O2, Application In Synthesis of 35112-27-7.
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