Rajasekhar, M. published the artcileSynthesis and antimicrobial activity of novel chalcone analogues bearing 2-furan trifluoromethyl ring, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is chalcone preparation antibacterial activity; apocynin ethyl trifluoro acetoacetate benzaldehyde fluorinated Claisen Schmidt reaction.
Preparation of chalcone I (R = 4-Cl, 2-CF3, 3-CF3, etc.) derivatives from Et 4,4,4-trifluoroacetoacetate and apocynin and their antibacterial activity. All the compounds I were screened in-vitro (at a concentration: 10 μg/disk) for their antibacterial activity against two gram-pos. strains (Staphylococcus aureus and Bacillus subtilis) and two gram-neg. strains (Escherichia coli and Pseudomonas aeruginosa). Results of the antibacterial data revealed that among all the compounds tested, compound I (R = 2-CF3, 3-CF3, 4-CF3, 4-OCF3, 4-OCHF3) showed excellent activity, while compounds I (R = 4-F, 2,4-F2, 3,4-F2, 2,6-F2) displayed good activity against all the tested bacteria.
Journal of Applicable Chemistry (Lumami, India) published new progress about Antibacterial agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Application of 2-Chloro-3-(trifluoromethyl)benzaldehyde.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics