Ruso, Jayaraman Sembian published the artcileOxidative cyclisation based one-pot synthesis of 3-substituted[1,2,4]triazolo[4,3-b]pyridazines using Me4NBr/oxone, Synthetic Route of 93118-03-7, the main research area is triazolopyridazine derivative preparation oxidative cyclization.
A facile one-pot synthesis of 3-substituted triazolopyridazine and thieno-triazolopyridazine derivatives is described. This protocol involves the preparation of heteroaryl hydrazone from the aldehyde and pyridazinohydrazine derivative followed by subjecting the intermediate directly to oxidative cyclization to assemble the desired 1,2,4-triazole moiety by employing the mixture of Me4NBr and oxone. This condition is efficient and is able to tolerate wide range of functional groups.
Journal of the Korean Chemical Society published new progress about Oxidative cyclization. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Synthetic Route of 93118-03-7.
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