Thota, Sreekanth published the artcileSynthesis, characterization, DNA binding, DNA cleavage, protein binding and cytotoxic activities of Ru(II) complexes, HPLC of Formula: 61343-99-5, the main research area is preparation ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; DNA interaction ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; cytotoxic activity ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; anticancer activity ruthenium phenylpyrrolyl dihydropyrazole carbothioamide bpy phen complex; Antiproliferative; Bovine serum albumin; DNA-binding; Ru(II) compounds.
The authors report on the synthesis of novel Ru(II) compounds (Ru-1 to Ru-8: I, II) bearing R-pdc, 4-Cl-pbinh ligands (R = 4-CF3, 4-F, 4-OH pdc = 3-phenyl-5-(1H-pyrrol-2-yl)-4,5-dihydro-1H-pyrazole-1-carbothioamide, pbinh = phenoxybenzylidene isonicotinyl hydrazides) and their in vitro antitumor activity toward the cell lines murine leukemia L1210, human lymphocyte CEM, human epithelial cervical carcinoma HeLa, BEL-<7402≥ and Molt4/C8. Some of the complexes exhibited more potent antiproliferative activity against cell lines than the standard drug cisplatin. Ruthenium complex Ru-2 displayed potent cytotoxicity with than that of cisplatin. DNA-binding, DNA cleavage and protein binding properties of ruthenium complexes with these ligands are reported. Interactions of these ruthenium complexes with DNA revealed an intercalative mode of binding between them. Synchronous fluorescence spectra proved that the interaction of ruthenium complexes with bovine serum albumin (BSA) resulted in a conformational change of the latter. International Journal of Biological Macromolecules published new progress about Antiproliferative agents. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, HPLC of Formula: 61343-99-5.
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