Van Orden, Lori Jean published the artcileA novel class of 3-(phenoxy-phenyl-methyl)-pyrrolidines as potent and balanced norepinephrine and serotonin reuptake inhibitors: Synthesis and structure-activity relationships, Product Details of C6H3ClFI, the main research area is norepinephrine serotonin reuptake inhibitor phenoxyphenylmethylpyrrolidine preparation structure activity.
A series of 3-(phenoxy-phenyl-methyl)-pyrrolidine analogs were discovered to be potent and balanced norepinephrine (NE) and serotonin (5-hydroxytryptamine, 5-HT) reuptake inhibitors. Several of these compounds were identified to have suitable in vitro pharmacokinetic properties for an orally dosed and CNS-targeted drug. Compound 39b, in particular, was identified as a potent NET and SERT reuptake inhibitor (NSRI) with minimal off-target activity and demonstrated robust efficacy in the spinal nerve ligation model of pain behavior.
Bioorganic & Medicinal Chemistry Letters published new progress about 5-HT reuptake inhibitors. 6797-79-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoroiodobenzene, and the molecular formula is C6H3ClFI, Product Details of C6H3ClFI.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics