Evans, Karen A. published the artcileAmino acid anthranilamide derivatives as a new class of glycogen phosphorylase inhibitors, Synthetic Route of 3032-32-4, the main research area is amino acid anthranilamide preparation glycogen phosphorylase inhibitor SAR.
A series of amino acid anthranilamide derivatives identified from a high-throughput screening campaign as novel, potent, and glucose-sensitive inhibitors of human liver glycogen phosphorylase a are described. A solid-phase synthesis using Wang resin was also developed which provided efficient access to a variety of analogs, and resulted in the identification of key structure-activity relationships, and the discovery of the potent exemplar I (IC50 = 80 nM). The SAR scope, synthetic strategy, and in vitro results for this series are presented herein.
Bioorganic & Medicinal Chemistry Letters published new progress about Antidiabetic agents. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Synthetic Route of 3032-32-4.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics