Krupkova, Sona published the artcile4-Chloro-2-Fluoro-5-Nitrobenzoic Acid as a Possible Building Block for Solid-phase Synthesis of Various Heterocyclic Scaffolds, Category: chlorides-buliding-blocks, the main research area is benzimidazole benzotriazole benzodiazepinedione succinimide solid phase synthesis; benzoic acid chloro fluoro nitro heterocyclic building block.
4-Chloro-2-fluoro-5-nitrobenzoic acid is a com. available multireactive building block that can serve as a starting material in heterocyclic oriented synthesis (HOS) leading to various condensed nitrogenous cycles. This work describes the use of this compound for the preparation of substituted nitrogenous heterocycles having 5-7-membered cycles via polymer-supported o-phenylenediamines. Immobilization of this acid on Rink resin via nucleophilic aromatic substitution of fluorine followed by further chlorine substitution, reduction of a nitro group and appropriate cyclization afforded benzimidazoles, benzotriazoles, quinoxalinones, benzodiazepinediones and succinimides. The method developed is suitable for the synthesis of diverse libraries including the mentioned types of heterocycles, which have significant importance in current drug discovery. The limitations of this method and unsuccessful attempts to prepare an 8-membered benzodiazocine ring are also reported.
ACS Combinatorial Science published new progress about Heterocyclization. 35112-05-1 belongs to class chlorides-buliding-blocks, name is 4-Chloro-2-fluoro-5-nitrobenzoic acid, and the molecular formula is C7H3ClFNO4, Category: chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics