Mao, Qi published the artcileIdentification of Novel 1-O-Substituted Aporphine Analogues as Potent 5-HT2C Receptor Agonists, Synthetic Route of 32345-60-1, the main research area is serotonin 5HT2C receptor 5HT2B receptor 5HT2A receptor agonist aporphine; 5-HT2A receptor; 5-HT2B receptor; 5-HT2C receptor; Serotonin; agonist; aporphine.
The 5-HT2C receptor has emerged as a promising target in the treatment of a variety of central nervous system disorders. We have first identified aporphines as a new class of 5-HT2C receptor agonists. Structure-activity relationship results indicate that the aporphine core may be required for 5-HT2C receptor activity, and substitutions at its C1 position are important for 5-HT2C receptor activity. Our efforts to optimize our hit 15781 lead to the identification of the highly potent and selective 5-HT2C agonist 18b (MQ02-439) with an EC50 value of 104 nM and weak antagonism at the 5-HT2A and 5-HT2B receptors. The findings may serve as good starting points for the development of more potent and selective 5-HT2C agonists as valuable pharmacol. tools or potential drug candidates.
ACS Chemical Neuroscience published new progress about 5-HT2A antagonists. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, Synthetic Route of 32345-60-1.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics