Mayr, Stefanie published the artcileSize-Driven Inversion of Selectivity in Esterification Reactions: Secondary Beat Primary Alcohols, Category: chlorides-buliding-blocks, the main research area is secondary primary alc acylation anhydride esterification selectivity MSPR.
Relative rates for the Lewis base-mediated acylation of secondary and primary alcs. carrying large aromatic side chains with anhydrides differing in size and electronic structure have been measured. While primary alcs. react faster than secondary ones in transformations with monosubstituted benzoic anhydride derivatives, relative reactivities are inverted in reactions with sterically biased 1-naphthyl anhydrides. Further anal. of reaction rates shows that increasing substrate size leads to an actual acceleration of the acylation process, the effect being larger for secondary as compared to primary alcs. Computational results indicate that acylation rates are guided by noncovalent interactions (NCIs) between the catalyst ring system and the DED substituents in the alc. and anhydride reactants. Thereby stronger NCIs are formed for secondary alcs. than for primary alcs.
Journal of Organic Chemistry published new progress about Activation enthalpy. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Category: chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics