Peng, Zhenghong published the artcileDegrasyn-like symmetrical compounds: Possible therapeutic agents for multiple myeloma, Synthetic Route of 286474-59-7, the main research area is degrasyn analog preparation antitumor multiple myeloma; Degrasyn; Inhibitors; Jak2/Stat3; Multiple myeloma; Small molecules; Synthesis.
A series of degrasyn-like sym. compounds, e.g. I [R = indol-3-yl, 4-(piperidin-1-yl)phenyl, 6-methoxypyridin-2-yl, etc.] have been designed, synthesized, and screened against B cell malignancy (multiple myeloma, mantle cell lymphoma) cell lines. The lead compounds T5165804 and CP2005 showed higher nanomolar potency against these tumor cells in comparison to degrasyn and inhibited Usp9x activity in vitro and in intact cells. These observations suggest that this new class of compounds holds promise as cancer therapeutic agents.
Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 286474-59-7 belongs to class chlorides-buliding-blocks, name is 6-Chloro-2-fluoro-3-methylbenzaldehyde, and the molecular formula is C8H6ClFO, Synthetic Route of 286474-59-7.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics