Wilson, Jennifer M. published the artcileSynthesis of 5-deazaflavin derivatives and their activation of p53 in cells, Name: 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is structure deazaflavin derivative preparation p53 antitumor apoptosis E3 HMD2.
A family of 5-deazaflavin derivatives has been synthesized using a two-step convergent strategy. The biol. activity of these compounds was evaluated in cells, by assessing their ability to stabilize and activate p53. These compounds may act as low mol. weight inhibitors of the E3 activity of HMD2 in tumors that retain wild-type p53. Importantly, we have demonstrated that the nitro group present in all three of the original lead compounds [1-3 (HL198C-E)] is not essential for observation of this biol. activity.
Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Name: 2-Chloro-3-(trifluoromethyl)benzaldehyde.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics