Archibald, John L. published the artcileDesign of an antithrombotic-antihypertensive agent (Wy 27569). Synthesis and evaluation of a series of 2-heteroaryl substituted dihydropyridines, Recommanded Product: 2-Chloro-3-(trifluoromethyl)benzaldehyde, the main research area is pyridine heteroaryl preparation antithrombotic antihypertensive; antithrombotic antihypertensive heteroaryldihydropyridine.
An approach to the design of potential combined antithrombotic-antihypertensive agents is described. A series of 1,4-dihydropyridines bearing a 1H-imidazol-1-yl or pyrid-3-yl substituted side chain in the 2-position, e.g. I (R, R1 = Me, Et; R2 = 3-pyridyl, 1-imidazolyl, R3 = 2, 3-NO2, X = CH2, CH2O) were synthesized and tested for antihypertensive activity in spontaneously hypertensive rats and for inhibition of TXA2 synthetase in rabbit platelets, in vitro. I (R = Et, R1 = Me, R2 = 1-imidazolyl, R3 = 3-NO2, X = CH2) (II) was shown to be similar in potency to nitrendipine as an antihypertensive agent. II inhibited TXA2 synthetase in rabbit and human platelets in vitro and reduced plasma TXB2 levels in rats at antihypertensive dose levels. The reductions in thromboxane production observed in vivo and in vitro were accompanied by enhanced levels of 6-KPGF1α, reflecting diversion of the arachidonic acid cascade towards prostacyclin synthesis.
Journal of Medicinal Chemistry published new progress about Anticoagulants. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Recommanded Product: 2-Chloro-3-(trifluoromethyl)benzaldehyde.
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Chlorides – an overview | ScienceDirect Topics