Berg, Arne published the artcileMetalation of pyrene, Application of Pyrene-2-carboxylic acid, the main research area is .
By the action of excess BuLi in Et2O, pyrene (I) is not only metalated, as evidenced by pyrenecarboxylic acid formation on carbonation of the reaction mixture, but is also attacked in the 1, 3, and 4 positions in the ratio of 2:1:0.2. In a typical experiment, 85% I is converted to pyrene-1-carboxylic acid (II), m. 275-6° (PhCl) [Me ester, m. 107-8° (MeOH)], 3-isomer, m. 273° (AcOH-PhCl) [Me ester, m. 83-4° (MeOH)] and 4-isomer, m. 327-8° (AcOH-PhCl) [Me ester, m. 139° (MEOH)]. II with LiAlH4 in Et2O refluxed 5 hrs. gave 1-pyrenylcarbinol (III), m. 155-5.5°. The chloride of III treated with LiAlH4 in boiling Et2O and the product chromatographed from 1:1 C6H6-C6H14 on alumina gave 1-methylpyrene, m. 147.5-8.0° (EtOH) [picrate, m. 228-9° (C6H6)].
Acta Chemica Scandinavica published new progress about Metalation. 36428-96-3 belongs to class chlorides-buliding-blocks, name is Pyrene-2-carboxylic acid, and the molecular formula is C17H10O2, Application of Pyrene-2-carboxylic acid.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics