Georgiadis, Taxiarchis M. published the artcileSolid-phase synthesis of an oxalic acid amide library, Related Products of chlorides-buliding-blocks, the main research area is oxalic acid amide library solid phase synthesis; Wang resin bound oxaloyl chloride amidation; arylamine amidation resin bound oxaloyl chloride.
Monoamides of oxalic acid are of interest as bioisosteric replacements for phosphate groups in the design of enzyme inhibitors. The use of oxalic acid as a linker to the Wang resin in the synthesis of individual or libraries of phosphate biosteres is demonstrated. The highly reactive resin-bound acid chloride reacts with arylamines to yield resin-bound N-aryloxamic acids (oxanilic acids). This methodol. is especially useful for the rapid synthesis of 2-(oxalylamino)benzoic acids, because it can be utilized for library synthesis and eliminates the intermediate purification step necessary in solution-phase reactions. The products are cleaved off the resin with trifluoroacetic acid in dichloromethane in good yields.
Journal of Combinatorial Chemistry published new progress about Amidation. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Related Products of chlorides-buliding-blocks.
Referemce:
Chloride – Wikipedia,
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