Neilson, Douglas G. published the artcilePreparation of optically active 3-aryl-1,4-dioxaspiro[4.5]decanes and their 2-oxo derivatives; Cotton effects associated with these compounds, HPLC of Formula: 32345-60-1, the main research area is dioxaspirodecanes ORD; phenyl dioxaspirodecanes ORD; Cotton effect dioxaspirodecanes; mandelates dioxaspirodecanes; dioxolanes ORD; spiro dioxolanes ORD.
Optically active mandelic acids, ArCH(OH)CO2H (I), were prepared including I (Ar = 3,4-(methylenedioxy)phenyl, m-MeO-C6H4, and ο-BrC6H4), which had not been resolved previously. I reacted with cyclohexanone to give 3-aryl-1,4-dioxaspiro[4.5]-decan-2-ones (II). The signs of the Cotton effects agreed with those predicted by the lactone sector rule. LiAlH4 reduction of I gave glycols ArCH(OH)CH2OH, which reacted with cyclohexanone to give 2-aryl-1,4-dioxaspiro[4.5]decanes (III). III provided a skeletal background which showed up more clearly the Cotton effects associated with the lactone keto group. Changes in ORD characteristics of PhCH(OH)CH2OH on successive methylation of the OH groups were recorded.
Journal of the Chemical Society [Section] C: Organic published new progress about Cotton effect. 32345-60-1 belongs to class chlorides-buliding-blocks, name is (S)-Methyl 2-(2-chlorophenyl)-2-hydroxyacetate, and the molecular formula is C9H9ClO3, HPLC of Formula: 32345-60-1.
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