Ni, Nanting published the artcileInhibition of quorum sensing in Vibrio harveyi by boronic acids, COA of Formula: C7H7BClFO2, the main research area is boronate inhibition quorum sensing Vibrio.
Bacterial quorum sensing refers to the ability of bacteria to control gene expression through the detection of a threshold concentration of certain chems. called autoinducer(s), which are secreted by self and/or other bacteria. Quorum sensing is implicated in the regulation of pathol. relevant events such as biofilm formation, virulence, conjugation, sporulation, and swarming mobility. Inhibitors of bacterial quorum sensing are valuable research tools and potential antimicrobial agents. Here, the authors describe the discovery of several boronic acid inhibitors of bacterial quorum sensing in Vibrio harveyi with IC50 values in the low to sub-micromolar range in whole cell assays.
Chemical Biology & Drug Design published new progress about Quorum sensing. 1072952-42-1 belongs to class chlorides-buliding-blocks, name is (5-Chloro-2-fluoro-4-methylphenyl)boronic acid, and the molecular formula is C7H7BClFO2, COA of Formula: C7H7BClFO2.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics