Ohi, Nobuhiro published the artcileSemisynthetic β-lactam antibiotics. III. Effect on antibacterial activity and COMT susceptibility of chlorine introduction into the catechol nucleus of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2-phenylacetamido]penicillanic acid, Name: 3-Chloro-4-hydroxy-5-methoxybenzoic acid, the main research area is penicillanic acid antibacterial; catechol methyl transferase metabolism penicillinate.
The resistance of 6-[(R)-2-[3-(3,4-dihydroxybenzoyl)-3-(3-hydroxypropyl)-1-ureido]-2-phenylacetamido]penicillanic acid (I) [81819-61-6] to metabolism by catechol-O-methyl-transferase [9012-25-3] was increased by introduction of the Cl atom into the catechol moiety. Penicillins having 1 or 2 Cl atoms at the positions adjacent to the OH had greater stability to COMT. This resulted in greater efficiency in vivo in exptl. Pseudomonas aeruginosa and Escherichia coli infections. In vitro activities were essentially unchanged.
Journal of Antibiotics published new progress about Escherichia coli. 62936-23-6 belongs to class chlorides-buliding-blocks, name is 3-Chloro-4-hydroxy-5-methoxybenzoic acid, and the molecular formula is C8H7ClO4, Name: 3-Chloro-4-hydroxy-5-methoxybenzoic acid.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics