Okuzumi, Tatsuya published the artcileEfficient solid-phase synthesis of quinazoline-2,4-diones with various substituents on aromatic rings, Product Details of C7H5Cl2NO2, the main research area is solid phase synthesis quinazolinedione electron withdrawing substituent; anthranilamide formation solid support cyclization carbonyldiimidazole.
The authors have developed a method for the solid-phase synthesis of quinazoline-2,4-diones with various substituents on the aromatic ring. Although there were numerous reports of the solid-phase synthesis of quinazoline-2,4-diones, they were not applicable to the synthesis of the quinazoline-2,4-diones with electron-withdrawing substituents on the aromatic ring. Considering the poor nucleophilicity of the amino group of anthranilic acids, coupling of anthranilic acids to solid-supported amines was studied without protecting the amino group. Various anthranilamides were prepared using anthranilic acids with electron-withdrawing substituents because a wide range of anthranilic acids are com. available. These anthranilamides were successfully cyclized with carbonyldiimidazole to give quinazoline-2,4-diones with high purity.
Tetrahedron published new progress about Cyclization. 3032-32-4 belongs to class chlorides-buliding-blocks, name is 2-Amino-3,6-dichlorobenzoic acid, and the molecular formula is C7H5Cl2NO2, Product Details of C7H5Cl2NO2.
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