Puleo, Thomas R. published the artcileCatalytic α-Selective Deuteration of Styrene Derivatives, Quality Control of 93118-03-7, the main research area is deuterostyrene regioselective chemoselective preparation; regioselective monodeuteration electron deficient styrene base catalyzed addition alc; dependence styrene deuteration chemoselectivity alc concentration.
Styrenes such as 4-trifluoromethylstyrene (particularly electron-deficient styrenes) underwent chemoselective and regioselective α-deuteration with DMSO-d6 in the presence of alcs. (either methanol or 1-cyclopropylethanol) and KO-t-Bu via base-catalyzed reversible addition of alkoxides to styrenes. The concentration of methanol is critical for high yields and selectivities to maximize the yield of deuteration over formation of polystyrenes; 1-cyclopropylethanol minimized the formation of nucleophilic substitution product in the monodeuteration of 2-chloro-3-vinylpyridine. The deuterated styrenes were used in the preparation of compounds with deuterated benzylic stereocenters.
Journal of the American Chemical Society published new progress about Chemoselectivity. 93118-03-7 belongs to class chlorides-buliding-blocks, name is 2-Chloro-3-(trifluoromethyl)benzaldehyde, and the molecular formula is C8H4ClF3O, Quality Control of 93118-03-7.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics