Tripathi, Laxmi published the artcileAnticonvulsant and neurotoxicity evaluation of some novel cyclohexyl-[4-substituted benzylidene/2-oxo-1,2-dihydro-indol-3-ylidene]thiosemicarbazides, Application In Synthesis of 61343-99-5, the main research area is cyclohexyl amine reaction carbon sulfide hydrazine; thiosemicarbazide cyclohexyl preparation condensation aryl aldehyde; isatin condensation cyclohexyl thiosemicarbazide; arylidene thiosemicarbazide preparation anticonvulsant neurotoxicity activity; indolonylidene thiosemicarbazide preparation anticonvulsant neurotoxicity activity; thiosemicarbazone preparation anticonvulsant neurotoxicity activity.
A series of novel cyclohexyl-[4-substituted benzylidene/2-oxo-1,2-dihydro-indol-3-ylidene]thiosemicarbazides were synthesized and screened for anticonvulsant activity in maximal electroshock induced seizure (MES) and s.c. metrazol (scMET) induced seizure models in mice. The neurotoxicity was assessed using the rotorod method. The compounds cyclohexyl-[4-(4-chlorophenoxy)-benzylidene]thiosemicarbazide and cyclohexyl-[2-oxo-1,2-dihydro-indol-3-ylidene]thiosemicarbazide emerged as the most promising one with anti-MES activity in mice i.p. All the compounds exhibited no neurotoxicity in rotorod method.
Asian Journal of Chemistry published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, Application In Synthesis of 61343-99-5.
Referemce:
Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics