Tripathi, Laxmi published the artcileDesign & synthesis of N’-[substituted] pyridine-4-carbohydrazides as potential anticonvulsant agents, SDS of cas: 61343-99-5, the main research area is pyridine carbohydrazide derivative preparation anticonvulsant activity neurotoxicity; pharmacophore pharmacokinetic docking pyridinecarbohydrazide.
A series of N’-[substituted] pyridine-4-carbohydrazides were designed and synthesized keeping in view the structural requirement of pharmacophore and evaluated for anticonvulsant activity and neurotoxicity. The anticonvulsant activity of the titled compounds was established after i.p. administration in three seizure models, which include MES, scMET and 6 Hz model. The most active compound of the series was N’-[4-(4-fluorophenoxy)benzylidene]pyridine-4-carbohydrazide (I), which showed a MES ED50 value of 128.3 mg/kg and 6 Hz ED50 value of 53.3 mg/kg in mice. The median toxic dose (TD50) was 343.6 mg/kg, providing compound I with a protection index of 2.67 in the MES test and 6.44 in 6 Hz test. A computational study was also carried out, including calculation of pharmacophore pattern, prediction of pharmacokinetic properties and docking studies.
European Journal of Medicinal Chemistry published new progress about Anticonvulsants. 61343-99-5 belongs to class chlorides-buliding-blocks, name is 4-(4-Chlorophenoxy)benzaldehyde, and the molecular formula is C13H9ClO2, SDS of cas: 61343-99-5.
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Chloride – Wikipedia,
Chlorides – an overview | ScienceDirect Topics